A total of 425 hemorrhaging peptic ulcer cases during the years 1958 to 1962, inclusive were carefully investigated, tabulated and matched with daily, weekly and monthly temperature changes at Honolulu, Hawaii. No evidence of a relationship between changes in temperature and the incidence of hemorrhaging ulcers was found. A seasonal variation of higher incidence in February–March, May, and October–November was observed despite a relatively fixed temperature environment. A comparison of the seasonal variation in peptic ulcer disease at two locations with dissimilar climates, namely, Philadelphia and Honolulu is also included in the study.

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