Projected changes in the South American monsoon system by the end of the twenty-first century are analyzed using the Community Earth System Model Large Ensemble (CESM-LENS). The wet season is shorter in LENS when compared to observations, with the mean onset occurring 19 days later and the mean retreat date 21 days earlier in the season. Despite a precipitation bias, the seasonality of rainfall over South America is reproduced in LENS, as well as the main circulation features associated with the development of the South American monsoon. Both the onset and retreat of the wet season over South America are delayed in the future compared to current climate by 3 and 7 days, respectively, with a slightly longer wet season. Central and southeastern Brazil are projected to get wetter as a result of moisture convergence from the strengthening of the South Atlantic low-level jet and a weaker South Atlantic subtropical high. The Amazon is projected to get drier by the end of the century, negatively affecting rain forest productivity. During the wet season, an increase in the frequency and intensity of extreme precipitation events is found over most of South America, and especially over northeastern and southern Brazil and La Plata. Meanwhile, during the dry season an increase in the maximum number of consecutive dry days is found over northeastern Brazil and the northern Amazon.