Monsoon low-pressure systems (MLPSs) are among the most important synoptic-scale disturbances of the South Asian summer monsoon. Potential changes in their characteristics in a warmer climate would have broad societal impacts. Yet, the findings from a few existing studies are inconclusive. We use the Geophysical Fluid Dynamics Laboratory (GFDL) coupled climate model CM4.0 to examine the projected changes in the simulated MLPS activity under a future emission scenario. It is shown that CM4.0 can skillfully simulate the number, genesis location, intensity and lifetime of MLPSs. Global warming gives rise to a significant decrease in MLPS activity. An analysis of several large-scale environmental variables, both dynamic and thermodynamic, suggests that the decrease in MLPS activity can be attributed mainly to a reduction in low-level relative vorticity over the core genesis region. The decreased vorticity is consistent with weaker large-scale ascent, which leads to less vorticity production through the stretching term in the vorticity equation. Assuming a fixed radius of influence, the projected reduction in MLPSs would significantly lower the associated precipitation over the north central India, despite an overall increase in mean precipitation.