Mean daily to monthly precipitation averages peak in late July over eastern Colorado and some of the most damaging Front Range flash floods have occurred because of extreme 1-day rainfall events during this period. Tree-ring chronologies of adjusted latewood width in ponderosa pine from eastern Colorado are highly correlated with the highest 1-day rainfall totals occurring during this 2-week precipitation maximum in late July. A regional average of four adjusted latewood chronologies from eastern Colorado was used to reconstruct the single wettest day observed during the last two weeks of July. The regional chronology was calibrated with the CPC 0.25° × 0.25° Daily U.S. Unified Gauge-Based Analysis of Precipitation dataset and explains 65% of the variance in the highest 1-day late July precipitation totals in the instrumental data from 1948 to 1997. The reconstruction and instrumental data extend fully from 1779 to 2019 and indicate that the frequency of 1-day rainfall extremes in late July has increased since the late eighteenth century. The largest instrumental and reconstructed 1-day precipitation extremes are most commonly associated with the intrusion of a major frontal system into a deep layer of atmospheric moisture across eastern Colorado. These general synoptic conditions have been previously linked to extreme localized rainfall totals and widespread thunderstorm activity over Colorado during the summer season. Chronologies of adjusted latewood width in semiarid eastern Colorado constitute a proxy of weather time-scale rainfall events useful for investigations of long-term variability and for framing natural and potential anthropogenic forcing of precipitation extremes during this 2-week precipitation maximum in a long historical perspective.