The NCEP CFSv2 and ECMWF hindcasts are used to explore the deterministic subseasonal predictability of the 850 hPa circulation of a large domain over the Atlantic and Indian Oceans that is relevant to the weather and climate of the southern African region. For NCEP CFSv2, twelve years of hindcasts, starting on 1 January 1999 and initialized daily for four ensemble members up to 31 December 2010 are verified against ERA-Interim reanalysis data. For ECMWF, 20 years of hindcasts (1995-2014), initialized once a month for all the months of the year are employed in a parallel analysis to investigate the predictability of the 850 hPa circulation. The ensemble mean for 7-day moving averages are used to assess the prediction skill for all the start dates in each month of the year, with a focus on the start dates in each month that are representative of the week 3 and 4 hindcasts. The correlation between the anomaly patterns over the study domain shows skill over persistence up into the week 3 hindcasts for some months. The spatial distribution of the correlation between the anomaly patterns show skill over persistence to notably reduce over the domain by week 3. A prominent area where prediction skill survives the longest, occur over central South America and the adjacent Atlantic Ocean.